There has been an article by E. Nent and colleagues last year:
“Histamine 4 receptor plays an important role in auto-antibody-induced
arthritis” (Int. Immunol. (2013) 25 (7): 437-443. doi: 10.1093/intimm/dxt008
First published online: April 1, 2013). The authors induced arthritis in mice
and found that “mice treated with all four histamine receptor antagonists
simultaneously showed no arthritic symptoms, while positive control mice
injected with K/B×N serum and vehicle suffered from severe symptoms. When
antagonists specific for HR1–4 were applied individually, only the HR4
antagonist clozapine could protect mice from arthritis, reflecting its
expression and functionality in the immune system.”
The HR4 is highly expressed in bone marrow and neutrophils and regulates
the release of certain cells from the marrow into the blood. It’s far too early
to think about therapeutic approaches in rheumatoid arthritis. However the idea
isn’t new as an anti-histamine drug against rheumatoid arthritis has been
tested in 1952 (http://ard.bmj.com/content/12/1/38.full.pdf).
D.C. Wilson’s summary has been disillusioning: “An investigation into the
usefulness of Phenergan in the treatment of rheumatoid arthritis is described. Eleven
cases (ten rheumatoid) were treated. There was a uniform lack of objective
response.”
As some patients disclose a
reduction of symptoms with an anti-histamine diet, I’d say, perhaps give it a
try even before more scientific data emerges. Eat fresh and avoid processed
foods. Look for more information here: http://www.histamineintolerance.org.uk/about/the-food-diary/the-food-list
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